Question: A 53 year old male undergoes transoral laser microsurgery for a T2N2bM0 squamous cell carcinoma of the left palatine tonsil. Pathology reveals a moderately to poorly differentiated SCC that is P16 positive. Which gene(s) is/are responsible for tumorigenesis in this patient? [Answer will be posted with next week's new question]

Answer to last week's question, "The Telescoping Nose" (April 25, 2016):

Markowitz class 1.