Cochrane Database of Systematic Reviews

TABLE OF CONTENTS

Facial Plastic surgery

1. General

Head & Neck Surgery

1. General Guidelines

2. Nasopharynx

3. Oropharynx

4. Thyroid
   

Laryngology

1. Dysphonia

2. Recurrent Respiratory Papillomatosis

3. Viral Laryngitis

Otology & Neurotology

1. Acute Otitis Media

2. Chronic Otitis Media

3. External Ear

4. Hearing Loss

5. Ménière's Disease

6. Ramsay Hunt Syndrome

7. Skull Base

8. Tinnitus

9. Vertigo
   

PEDIATRIC Otolaryngology

1. Adenoidectomy

2. Pharyngitis

3. Tonsillectomy


Rhinology & Sinus Surgery

1. Allergic Rhinitis

2. Common Cold & Cough

3. Epistaxis

4. Nasal Polyps

5. Sinusitis

Sleep surgery

1. Obstructive Sleep Apnea

Trauma

1. General

Facial Plastic surgery

• Graft interposition for preventing Frey's syndrome in patients undergoing parotidectomy (2019)

• Interventions for the treatment of Frey's syndrome (2015)

• Perioperative corticosteroids for preventing complications following facial plastic surgery (2014)

HEAD & NECk surgery

General Guidelines

• Immunonutrition for patients undergoing surgery for head and neck cancer (2018)

• Therapeutic exercises for affecting post‐treatment swallowing in people treated for advanced‐stage head and neck cancers (2016)

• Virtual reality training for improving the skills needed for performing surgery of the ear, nose or throat (2015)

• Psychosocial interventions for patients with head and neck cancer (2013)

• Enteral feeding methods for nutritional management in patients with head and neck cancers being treated with radiotherapy and/or chemotherapy (2013)

• Exercise interventions for shoulder dysfunction in patients treated for head and neck cancer (2012)

• Hyperfractionated or accelerated radiotherapy for head and neck cancer (2010)

• Erythropoietin as an adjuvant treatment with (chemo) radiation therapy for head and neck cancer (2009)

Nasopharynx

• Screening for nasopharyngeal cancer (2015)

• Radiotherapy versus open surgery versus endolaryngeal surgery (with or without laser) for early laryngeal squamous cell cancer (2014)

• Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma (2006)

Oropharynx

• Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment (2018)

• De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally invasive surgery for resectable HPV‐positive oropharyngeal carcinoma (2018)

• Minimally invasive surgery versus radiotherapy/chemoradiotherapy for small‐volume primary oropharyngeal carcinoma (2016)

• Interventions for the treatment of oral and oropharyngeal cancers: targeted therapy and immunotherapy (2015)

• De‐escalation treatment protocols for human papillomavirus‐associated oropharyngeal squamous cell carcinoma (2014)

• Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy (2011)

• Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy (2010)

Thyroid

• Recombinant human thyrotropin (rhTSH) aided radioiodine treatment for residual or metastatic differentiated thyroid cancer (2010)

• Angiogenesis‐inhibitors for metastatic thyroid cancer (2010)

• Radioiodine therapy for differentiated thyroid carcinoma with thyroglobulin positive and radioactive iodine negative metastases (2009)

LARYNGOLOGY

Dysphonia

• Alternative injectable materials for vocal fold medialisation in unilateral vocal fold paralysis (2012)

• Surgical versus non‐surgical interventions for vocal cord nodules (2012)

• Topical anaesthetic or vasoconstrictor preparations for flexible fibre‐optic nasal pharyngoscopy and laryngoscopy (2011)

• Interventions for preventing voice disorders in adults (2007)

• Interventions for treating functional dysphonia in adults (2007)

• Botulinum toxin injections for the treatment of spasmodic dysphonia (200

Recurrent Respiratory Papillomatosis

• Photodynamic therapy for recurrent respiratory papillomatosis (2014)

• Adjuvant antiviral therapy for recurrent respiratory papillomatosis (2012)

Viral Laryngitis

• Heliox for croup in children (2018)

• Glucocorticoids for croup in children (2018)

• Heated, humidified air for the common cold (2017)

• Antibiotics for acute laryngitis in adults (2015)

• Nebulized epinephrine for croup in children (2013)

Otology & Neurotology

Acute Otitis Media

• Probiotics for preventing acute otitis media in children (2019)

• Pneumococcal conjugate vaccines for preventing acute otitis media in children (2019)

• Grommets (ventilation tubes) for recurrent acute otitis media in children (2018)

• Systemic corticosteroids for acute otitis media in children (2018)

• Influenza vaccines for preventing acute otitis media in infants and children (2017)

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute otitis media in children (2016)

• Xylitol for preventing acute otitis media in children up to 12 years of age (2016)

• Antibiotics for acute otitis media in children (2015)

• Zinc supplements for preventing otitis media (2014)

• Once or twice daily versus three times daily amoxicillin with or without clavulanate for the treatment of acute otitis media (2013)

• Short‐course antibiotics for acute otitis media (2010)

• Antibiotics for the prevention of acute and chronic suppurative otitis media in children (2006)

• Topical analgesia for acute otitis media (2006)

Chronic Otitis Media

• Topical antiseptics for chronic suppurative otitis media (2020)

• Antibiotics versus topical antiseptics for chronic suppurative otitis media (2020)

• Topical antibiotics for chronic suppurative otitis media (2020)

• Interventions for children with ear discharge occurring at least two weeks following grommet (ventilation tube) insertion (2016)

• Antibiotics for otitis media with effusion in children (2016)

• Water precautions for prevention of infection in children with ventilation tubes (grommets) (2016)

• Autoinflation for hearing loss associated with otitis media with effusion (2013)

• Interventions for the prevention of postoperative ear discharge after insertion of ventilation tubes (grommets) in children (2013)

• Antihistamines and/or decongestants for otitis media with effusion (OME) in children (2011)

• Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children (2011)

• Grommets (ventilation tubes) for hearing loss associated with otitis media with effusion in children (2010)

• Adenoidectomy for otitis media in children (2010)

• Surgery for tympanic membrane retraction pockets (2010)

• Identification of children in the first four years of life for early treatment for otitis media with effusion (2007)

• Systemic antibiotics versus topical treatments for chronically discharging ears with underlying eardrum perforations (2006)

• Topical antibiotics without steroids for chronically discharging ears with underlying eardrum perforations (2005)

• Antibiotic prophylaxis in clean and clean‐contaminated ear surgery (2004)

External Ear

• Ear drops for the removal of ear wax (2018)

• Hyperbaric oxygen as an adjuvant treatment for malignant otitis externa (2013)

• Interventions for acute otitis externa (2010)

• Interventions for acute auricular haematoma (2004)

Hearing Loss

• Different infusion durations for preventing platinum‐induced hearing loss in children with cancer (2020)

• Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer (2019)

• Bilateral versus unilateral hearing aids for bilateral hearing impairment in adults (2017)

• Hearing aids for mild to moderate hearing loss in adults (2017)

• Interventions to prevent occupational noise‐induced hearing loss (2017)

• Interventions to improve hearing aid use in adult auditory rehabilitation (2016)

• Platinum‐induced hearing loss after treatment for childhood cancer (2016)

• Auditory‐verbal therapy for promoting spoken language development in children with permanent hearing impairments (2014)

• Steroids for idiopathic sudden sensorineural hearing loss (2013)

• Hyperbaric oxygen for idiopathic sudden sensorineural hearing loss and tinnitus (2012)

• Antivirals for idiopathic sudden sensorineural hearing loss (2012)

• Vasodilators and vasoactive substances for idiopathic sudden sensorineural hearing loss (2009)

Meniere's Disease

• Restriction of salt, caffeine and alcohol intake for the treatment of Ménière's disease or syndrome (2018)

• Positive pressure therapy for Ménière's disease or syndrome (2015)

• Surgery for Ménière's disease (2013)

• Intratympanic steroids for Ménière's disease or syndrome (2011)

• Intratympanic gentamicin for Ménière's disease or syndrome (2011)

• Diuretics for Ménière's disease or syndrome (2006)

• Betahistine for Ménière's disease or syndrome (2001)

Ramsay Hunt Syndrome (Herpes Zoster Oticus)

• Antiviral therapy for Ramsay Hunt syndrome (herpes zoster oticus with facial palsy) in adults (2008)

• Corticosteroids as adjuvant to antiviral treatment in Ramsay Hunt syndrome (herpes zoster oticus with facial palsy) in adults (2008)

Skull Base

• Stereotactic radiotherapy for vestibular schwannoma (2014)

Tinnitus

• Cognitive behavioural therapy for tinnitus (2020)

• Betahistine for tinnitus (2018)

• Sound therapy (using amplification devices and/or sound generators) for tinnitus (2018)

• Zinc supplementation for tinnitus (2016)

• Amplification with hearing aids for patients with tinnitus and co‐existing hearing loss (2014)

• Ginkgo biloba for tinnitus (2013)

• Sound therapy (masking) in the management of tinnitus in adults (2012)

• Hyperbaric oxygen for idiopathic sudden sensorineural hearing loss and tinnitus (2012)

• Antidepressants for patients with tinnitus (2012)

• Repetitive transcranial magnetic stimulation for tinnitus (2011)

• Anticonvulsants for tinnitus (2011)

• Cognitive behavioural therapy for tinnitus (2010)

• Tinnitus Retraining Therapy (TRT) for tinnitus (2010)

Vertigo

• Betahistine for symptoms of vertigo (2016)

• Vestibular rehabilitation for unilateral peripheral vestibular dysfunction (2015)

• Pharmacological agents for the prevention of vestibular migraine (2015)

• Vestibular rehabilitation for unilateral peripheral vestibular dysfunction (2015)

• The Epley (canalith repositioning) manoeuvre for benign paroxysmal positional vertigo (2014)

• Modifications of the Epley (canalith repositioning) manoeuvre for posterior canal benign paroxysmal positional vertigo (BPPV) (2012)

• Corticosteroids for the treatment of idiopathic acute vestibular dysfunction (vestibular neuritis) (2011)

• Scopolamine (hyoscine) for preventing and treating motion sickness (2011)

Pediatric otolarynology

Adenoidectomy

• Adenoidectomy for otitis media in children (2010)

• Intranasal corticosteroids for nasal airway obstruction in children with moderate to severe adenoidal hypertrophy (2008)

Pharyngitis

• Efficacy and safety of rapid tests to guide antibiotic prescriptions for sore throat (2020)

• Corticosteroids as standalone or add‐on treatment for sore throat (2020)

• Needle aspiration versus incision and drainage for the treatment of peritonsillar abscess (2016)

• Different antibiotic treatments for group A streptococcal pharyngitis (2016)

• Antibiotics for preventing recurrent sore throat (2015)

• Antibiotics for sore throat (2013)

• Short‐term late‐generation antibiotics versus longer term penicillin for acute streptococcal pharyngitis in children (2012)

• Chinese medicinal herbs for sore throat (2012)

• Topical anaesthetic or vasoconstrictor preparations for flexible fibre‐optic nasal pharyngoscopy and laryngoscopy (2011)

• Surgical interventions for pharyngeal pouch (2005)

Tonsillectomy

• Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA) (2019)

• Coblation versus other surgical techniques for tonsillectomy (2017)

• Tonsillectomy or adenotonsillectomy versus non‐surgical treatment for chronic/recurrent acute tonsillitis (2014)

• Oral rinses, mouthwashes and sprays for improving recovery following tonsillectomy (2013)

• Antibiotics to reduce post‐tonsillectomy morbidity (2012)

• Steroids for improving recovery following tonsillectomy in children (2011)

• Dissection versus diathermy for tonsillectomy (2011)

• Perioperative local anaesthesia for reducing pain following tonsillectomy (1999)

RHINOLOGY & SINUS SURGERY

Allergic Rhinitis

• Saline irrigation for allergic rhinitis (2018)

• Helminth therapy (worms) for allergic rhinitis (2012)

• Sublingual immunotherapy for allergic rhinitis (2010)

• Inferior turbinate surgery for nasal obstruction in allergic rhinitis after failed medical treatment (2010)

• Antihistamines used in addition to topical nasal steroids for intermittent and persistent allergic rhinitis in children (2010)

• House dust mite avoidance measures for perennial allergic rhinitis (2010)

• Allergen injection immunotherapy for seasonal allergic rhinitis (2007)

• Topical nasal steroids for intermittent and persistent allergic rhinitis in children (2007)

• Capsaicin for allergic rhinitis in adults (2006)

Common Cold & Cough

• Honey for acute cough in children (2018)

• Heated, humidified air for the common cold (2017)

• Vaccines for the common cold (2017)

• Nasal decongestants in monotherapy for the common cold (2016)

• Antihistamines for the common cold (2015)

• Corticosteroids for the common cold (2015)

• Non‐steroidal anti‐inflammatory drugs for the common cold (2015)

• Over‐the‐counter (OTC) medications for acute cough in children and adults in community settings (2014)

• Garlic for the common cold (2014)

• Echinacea for preventing and treating the common cold (2014)

• Acetaminophen (paracetamol) for the common cold in adults (2013)

• Intranasal ipratropium bromide for the common cold (2013)

• Antibiotics for the common cold and acute purulent rhinitis (2013)

• Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho‐pulmonary disease (2013)

• Vitamin C for preventing and treating the common cold (2013)

• Oral antihistamine‐decongestant‐analgesic combinations for the common cold (2012)

• Chinese medicinal herbs for the common cold (2007)

Epistaxis

• Tranexamic acid for patients with nasal haemorrhage (epistaxis) (2018)

• Interventions for recurrent idiopathic epistaxis (nosebleeds) in children (2012)

Nasal Polyps

• Perioperative local anaesthesia for reducing pain following septal surgery (2018)

• Topical nasal steroids for treating nasal polyposis in people with cystic fibrosis (2015)

• Surgical versus medical interventions for chronic rhinosinusitis with nasal polyps (2014)

• Surgical interventions for chronic rhinosinusitis with nasal polyps (2014)

Sinusitis

• Biologics for chronic rhinosinusitis (2020)

• Medical interventions for chronic rhinosinusitis in cystic fibrosis (2019)

• Antibiotics for acute rhinosinusitis in adults (2018)

• Topical and systemic antifungal therapy for chronic rhinosinusitis (2018)

• Cyclamen europaeum extract for acute sinusitis (2018)

• Intranasal steroids versus placebo or no intervention for chronic rhinosinusitis (2016)

• Saline irrigation for chronic rhinosinusitis (2016)

• Short‐course oral steroids alone for chronic rhinosinusitis (2016)

• Systemic and topical antibiotics for chronic rhinosinusitis (2016)

• Different types of intranasal steroids for chronic rhinosinusitis (2016)

• Short‐course oral steroids as an adjunct therapy for chronic rhinosinusitis (2016)

• Steroid‐eluting sinus stents for improving symptoms in chronic rhinosinusitis patients undergoing functional endoscopic sinus surgery (2015)

• Surgical versus medical interventions for chronic rhinosinusitis with nasal polyps (2014)

• Surgical interventions for chronic rhinosinusitis with nasal polyps (2014)

• Decongestants, antihistamines and nasal irrigation for acute sinusitis in children (2014)

• Functional endoscopic balloon dilation of sinus ostia for chronic rhinosinusitis (2011)

• Functional endoscopic sinus surgery for chronic rhinosinusitis (2006)

Sleep surgery

Sleep Apnea

• Tonsillectomy versus tonsillotomy for obstructive sleep‐disordered breathing in children (2020)

• Tonsillectomy or adenotonsillectomy versus non‐surgical management for obstructive sleep‐disordered breathing in children (2015)

• Surgery for obstructive sleep apnoea in adults (2005)

• Oral appliances for obstructive sleep apnoea (2006)

Trauma

General Trauma

• Tranexamic acid for patients with nasal haemorrhage (epistaxis) (2018)

• Interventions for treating traumatised ankylosed permanent front teeth (2015)

• Helmets for preventing injury in motorcycle riders (2008)

• Interventions for acute auricular haematoma (2004)

• Helmets for preventing head and facial injuries in bicyclists (1999)